Company Overview

Since its inception over a decade ago, CRISPR Therapeutics has transformed from a research-stage company advancing programs in the field of gene editing, to a company with a diverse portfolio of product candidates across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, cardiovascular and rare diseases. The Nobel Prize-winning CRISPR science has revolutionized biomedical research and represents a powerful, clinically validated approach with the potential to create a new class of potentially transformative medicines. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic partnerships with leading companies including Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California, and business offices in London, United Kingdom.

Position Summary 

We are seeking a highly motivated Senior Scientist to join our Analytical Development team focused on mRNA-based therapeutics. This individual will be a key contributor to method development and validation for mRNA and related modalities, working both hands-on in the lab and in collaboration with contract labs (CMOs/CROs). The successful candidate will bring a deep understanding of analytical methods, regulatory requirements, and a passion for innovation and problem-solving in a fast-paced environment. 

Responsibilities 

• Hands-on execution and development of analytical assays to characterize and quantify mRNA or related materials. 

• Design, perform, and provide guidance for method development, optimization, feasibility, transfer, qualification, and validation of analytical methods for internal and external stakeholders. 

• Serve as a technical lead and subject matter expert (SME) for analytical projects at CMOs/CROs, ensuring scientific rigor and regulatory compliance. 

• Design and execute comparability studies to support manufacturing process changes and product lifecycle management. 

• Author and review SOPs, analytical protocols, technical reports, and regulatory submission documents (e.g., IND, BLA). 

• Apply a range of analytical techniques including Chromatography, Mass spectrometry, Sequencing, electrophoresis, Safety and bio-assays relevant to mRNA products 

• Interpret and present complex analytical data with clarity to internal stakeholders and regulatory agencies. 

• Mentor and/or supervise junior scientists, providing guidance on experimental design, troubleshooting, and career development. 

• Collaborate cross-functionally with Research, Process Development, Quality, and Regulatory teams to support program advancement from preclinical through clinical and commercial stages. 

• Foster a culture of resilience, collaboration, and entrepreneurial thinking. 

Minimum Qualifications 

• PhD in Biochemistry, Molecular Biology, Analytical Chemistry, or related discipline with 5+ years of relevant industry experience, or non-PhD and 12+ years progressive, relevant experience.

• Proven expertise in developing and executing assays for mRNA or related products. 

• Experience working with external laboratories (CMOs/CROs) for method development and stage-appropriate validations. 

• Strong understanding of regulatory and compendial expectations (e.g., ICH, USP/Eur.Ph.) mRNA and for analytical methods. 

• Demonstrated experience in comparability assessments and analytical strategies supporting product changes. 

• Excellent written and verbal communication skills. 

• Ability to work independently and collaboratively in a dynamic, matrixed environment. 

Preferred Qualifications 

• Prior experience with analytical support for regulatory filings (e.g., IND, IMPD, BLA). 

• Familiarity with platform analytical approaches for mRNA therapeutics and LNP-formulated Cell and Gene Therapy products. 

• Demonstrated ability to lead cross-functional initiatives or technical teams. 

• Passion for science, high level of integrity, and a proactive mindset aligned with core values of collaboration, undaunted spirit, resilience, and entrepreneurship. 

Competencies 

• Collaborative – Openness, One Team 

• Undaunted – Fearless, Can-do attitude 

• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems. 

• Entrepreneurial Spirit – Proactive. Ownership mindset.​

​Due to the nature of their work, our manufacturing and lab-based positions are located fully on-site.